Fidock Lab at Columbia University Irving Medical Center

Antimalarial drug resistance in Plasmodium falciparum parasites, drug mode of action studies, transporter structure/function, hemoglobin endocytosis and heme detoxification.

Laboratory Contributions

• Gene editing (CRISPR/Cas9, zinc-finger nucleases)
• Drug dose-response profiling
• Cross-resistance studies
• Parasite survival assays
• Whole-genome sequence analyses
• Genetic crosses and Quantitative Trait Loci analysis
• Minimum inoculum of resistance profiling
• Fitness assays
• Structure/function profiling of transmembrane proteins including transporters