Winzeler Lab at the University of California, San Diego

The Winzeler lab conducts phenotypic screens and compound testing to accelerate the search for new malaria treatments and malaria prevention methods. We use chemical biology, in vitro evolution and whole genome sequencing to discover “chemically-validated” targets that can be used in structure guided drug design. We are interested in host pathogen signaling and how malaria parasites interact with human liver cells. And, we are using a variety of experimental systems, including yeast and human cells, to understand how drug resistance emerges.

Laboratory Contributions

• In-vitro evolution
• Target identification
• Assay development
• Target-based screening campaigns
• Plasmodium falciparum multi-stage phenotypic screens
• Program management