Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Journal:
Genome biology, Volume: 10, Issue: 2
Published:
February 13, 2009
PMID:
19216790
Authors:
Neekesh V Dharia NV, Amar Bir Singh Sidhu AB, María Belén Cassera MB, Scott J Westenberger SJ, Selina Er Bopp SE, Rich T Eastman RT, David Plouffe D, Serge Batalov S, Daniel J Park DJ, Sarah K Volkman SK, Dyann F Wirth DF, Yingyao Zhou Y, David A Fidock DA, Elizabeth A Winzeler EA
Abstract:

The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the development of new therapeutic agents, and provide information about the likely function of genes. Elucidating mechanisms of phenotypic drug resistance can also assist in identifying the mode of action of uncharacterized but potent antimalarial compounds identified in high-throughput chemical screening campaigns against Plasmodium falciparum.